Theophylline
                        ============

þ Theophylline for Asthma
 - IV aminophylline not useful for pediatric patients admitted with asthma.
   [DiGiulio GA, et al. Hospital trestment of asthma. Lack of benefit from
   theophylline given in addition to nebulized albuterol and intravenously
   administered corticosteroid. J Pediatr 1993;122(3):464.]
   [Carter E, et al. Efficacy of intravenously administered theophylline in
   children hospitalized with severe asthma. J Pediatr 1993;122(3):470.]
 - Even pooling studies still didn't reach significance. More side effects,
   may be additive with beta agonists.
   [Littenbuerg B. JAMA 1988;259:1678.]
 - large study, controlled, no change in PFTs but lowered admission rate with
   preset discharge criteria.
   [Wrenn K. Ann IM. 1991;115:241.]

þ Drugs that INcrease Theo Levels:
 - ciprofloxacin

þ Drugs that DEcrease Theo Levels:
 - phenytoin (e.g., Dilantin)
 - smoking
 - charcoal-broiled foods

þ See also:
  Theo Poisoning        <P-Theo.TXT>