Septic Arthritis ================ þ Big difference between antibioties at 24 vs. 48 hours in tissue destruction. [Parry CR Am J Orthopedics.] þ Most common cause is hematogenous. Search for other sources. þ 1:10,000 per case of joint aspiration. Rhuum Disease Clinics, 1997. þ Testing: - WBC ESR not useful: WBC 10K in 50%ESR > 50 in 70-90% cultures not even that useful WBC in joint fluid generally > 50,000 (some say 100K with >75% polys) (5000-50,000 in gout etc.)