Diagnosis of ^BUN/Cr ==================== þ Classification of ^BUN/Cr: - oliguric (<400 cc/24hrs) - non-oliguric (usually from nephrotoxins") - polyuric (usually from partial obstruction) - spurious (nonrenal): - ^ Creatinine from rhabdomyolysis - false + creatinine assay by older assays from high bilirubin levels, cefoxitin þ FENA: Fractional Excretion of Na+ - is the ratio of kidney's sodium clearance to the creatinine clearance - >1% suggests ATN - <1% suggests "prerenal azotemia" (or obstruction or acute glomerulonephritis) - equation: U * V Where Na+ -------- U is urine Na+ concentration P U * P Na+ Na+ Na+ Cr FeNa+ = ---------- = ----------- P is plasma Na+ concentration U * V P * U Na+ Cr Na+ Cr -------- (and similarly for Cr, creatinine) P Cr and V is the Volume of the sample þ Multi-factor analysis for ^BUN/Cr +--------------+--------+------+-------+------+-------------------------+ | | BUN/Cr | U | U/P | FENA | UA | | | | Na+ | Cr | | | +--------------+--------+------+-------+------+-------------------------+ | Prerenal | 20/1 | <20 | >40 | <1% | normal or protein casts | +--------------+--------+------+-------+------+-------------------------+ | Renal (?ATN) | 10/1 | >=40 | <20 | >1% | "dirty brown casts" | +--------------+--------+------+-------+------+-------------------------+