NSAID OVERDOSE
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þ NSAID OD Symptoms
 - (19% of cases.): mild CNS depression, GI upset.  Also, nystagmus, rash,
   transient decreased renal function, hypertension, bradycardia.  Two kids
   had seizures, one developed apnea and died from aspiration and sepsis.  All
   who developed symptoms did so within 4 hours.  Need over 400 mg/kg to even
   develop symptoms (e.g., 20 Advil).
 - Standard Rx in ER:  one dose of charcoal, observe for 6 hours.  Keep and
   follow BUN/Cr if older or ill. [Hall AH, et al. Ibuprofen overdose:
   126 cases.  Ann Emerg Med 15:1308,1986.]
 - A detailed review may be found in Med Tox 1:12, 1986.

þ Ibuprofen OD:
 - One review of uncomplicated ibuprofen ingestions found that all patients
   who were initially asymptomatic and remained that way for four hours never
   developed symptoms.  Based on this, it has been suggested that such
   patients can be considered "medically cleared" after a 4-6 hour period of
   observation after their ingestion. [Tintinalli 3rd ed. p 628.]

þ Narcan for ibuprofen OD:
 - casreports of bad ibuprofen OD responding to big doses of Narcan.
   <Narcan.TXT>