Household Products ================== þ See also Cleaning Products þ Fingernail Polish Remover: acetone and various alcohols. Accidental ingestion of 5-10 cc not a medical emergency; if amount verifiably small, no need for gastric decontamination. May need ipecac or gastric lavage for larger amounts. Charcoal useless. But, see Artifician Fingernail Remover below: þ Artificial Fingernail Remover: contain acetonitrile that decomposes to cyanide slowly. May cause delayed cyanide poisoning and death. [JAMA 1988; 260:3470-3473.] [Am J Emerg Med 1991; 9:264-267 _and_ 268-270 _and_ 271-272.] [Pediatrics 1991; 88:337-340.] þ Ethylene Glycol (anti-freeze): - rapid test for Ethylene Glycol: maybe soon. (SAEM 2004) - urine fluorescence: useless test, lots of false +. "This test is now dead." -Lewis Goldfrank, M.D., session moderator. [Parsa T. Can physicians detect fluorescence in children's urine? AEM 2004;11(5):530-531.] - is metabolized to oxalate (oxalic acid) which is poisonous; check urine for oxalate crystals. - treat with ethanol ingestion and Vitamin B6 (pyridoxine) IV and hemodialysis. - some devices read glycolic acid (metabolite) as lactate, Presby's does. - may have left-over metabolic acidosis even a couple of days later after the ethylene glycol is out of the system. - Also, fomepizole (e.g., Antizol(TM)) is available to use instead of ethanol See Also: þ Lysol - The major substance in Lysol is diethylene glycol(DEG). - studies on various rodents. The major effect included renal failure, hepatic failure, and myocardial myocytolysis. In 1990 there were several cases in Nigeria and Bangladesh where children presented to hospitals with fever, renal failure, acidosis, hypotension and hypogylcemia. They had all received paracetamol syrup for fever. DEG was found to be in these elixers with concentrations approaching 20%. There was a 100% mortality within 2 weeks in the Nigerian group with no hemodialysis used. Patients were treated with IVF and alkalinization. [Okuonghae HO, Ighogboja IS, Lawson JO, Nwana EJ. Diethylene glycol poisoning in Nigerian children Ann Trop Paediatr 1992;12(3):235-8.] Abstract: [Hanif M, Mobarak MR, Ronan A, Rahman D, Donovan JJ Jr, Bennish ML. Fatal renal failure caused by diethylene glycol in paracetamol elixir: the Bangladesh epidemic. BMJ 1995;311(6997):88-91.] Abstract: - Autopsy findings from several cases in Argentina disclosed the presence of hepatic, pancreatic and renal necrosis and the prominant lack of any evidence for calcium oxalate crystals unlike ethylene glycol poisoning. [Drut R, Quijano G, Jones MC, Scanferla P. [Pathologic findings in diethylene glycol poisoning] Medicina (B Aires) 1994;54(1):1-5.] Abstract: - Apparantly rare case reports of oxaluria have been reported, however. - Experimentally, it has been suggested that ethanol might protect patients from the toxic metabolites of DEG poisoning although the usefulness of this mode of therapy has not been universal. [Hébert JL, Auzépy P, Durand A. [Acute human and experimental poisoning with diethylene glycol] Sem Hop 1983;59(5):344-9.] Abstract: þ H2O2 Hydrogen Peroxide: - 3% solution used for medicinal purposes, - also commonly used in veterinary practice as an emetic. - Ingestion even of significant amounts not toxic. - However, stronger solutions can be quite corrosive.