Blood Cultures in Kids ====================== þ Does one need one or two blood cultures? - better sensitivity if (1) use single large volume culture instead of two smaller volumes, and (2) this also makes cultures turn positive sooner. Get a single BIG blood culture. [Isaacman DJ, Karasic RB, Reynolds EA, Kost SI. Effect of number of blood cultures and volume of blood cultures and volume of blood on detection of bactermia in children. J Pediatr 1996;128:190-195.]