Narcan (Naloxone)
                                =================
þ Unusual uses of Narcan

  - Naloxone has been shown to be useful in the reversal of CNS depression 
    induced by overdoses of several non-opioid drugs, including ibuprofen, 
    clonidine, tetrahydrozoline, and valproic acid. It has been suggested that 
    the mechanism for naloxone in treating valproic acid overdose may be 
    antagonism of gamma-aminobutyric acid (GABA), as well as reversal of 
    endogenous opioid effects. Naloxone has also been studied in adults for the 
    reversal of alcoholic coma and to improve circulation of patients in shock.
    (Have to use big doses, i.e., 10 mg)
    [Easley RB, Altemeier WA. Central nervous system manifestations of an 
    ibuprofen overdose reversed by naloxone. Pediatr Emerg Care 2000;16:39-
    41.]
    [Holmes JF, Berman DA. Use of naloxone to reverse symptomatic 
    tetrahydrozoline overdose in a child. Pediatr Emerg Care 1999;15:193-
    4.]
    [Roberge RJ, Francis EH. Use of naloxone in valproic acid overdose: case 
    report and review. J Emerg Med 2002;22:67-70.]