Metabolism ========== þ Hyperlipidemia þ Porphyria (common AIP=Acute Intermittent Porphyria) - Drugs that are safe for those with porphyria - Drugs that are UNsafe for those with porphyria Phenobarb and dilantin common triggers þ Porphyria Cutanea Tarda - blisters on sun-exposed skin - hirsute, onycholysis - urine fluoresces with Wood's light (470nm UVA) - sensitive to different drugs than AIP; BCPs common trigger - check urine and stool porphyrins - send for GI evaluation, hepatoma common complication þ Treatment of AIP (per Harrison's plus personal notes): - Demerol for pain - D10W at 200 cc/hr (20 g/hr) (Harrison's) - if fails, hematin IV - check for hyponatremia (common occurrence)