UNSafe Drugs for Patients with Acute Intermittent Porphyria, Variegate Porphyria, Hereditary Coproporphyria, or ALA Dehydratase Deficiency (Plumboporphyria) from Scientific American Medicine, 12/96. *Has produced conflicting results (occasionally positive but mainly negative) in experiments on porphyrinogenicity. None of the safe drugs listed has been associated with human porphyric attacks. +Has produced conflicting results (some positive, some negative) in experiments on porphyrinogenicity. ++Has been associated with acute attacks of porphyria. Unsafe Drugs---------------------------------------------------------- Alcuronium Drotaverine Alprazolam Dydrogesterone+ Aluminum preparations Aminoglutethimide Enflurane Aminopyrine Ergonovine maleate Amiodarone Ergotamine tartrate Amitriptyline+ Ergot compounds++ Amphetamines+ Erythromycin Amobarbital Ethamsylate Antipyrine Ethanol++ Apazone Ethchlorvynol++ Apronalide Ethinamate Auranofin Ethionamide Ethosuxamide Barbiturates++ Ethotoin Bemegride++ Etidocaine Bendroflumethiazide Etomidate Benoxaprofen Bromocriptine Floxacillin+ Busulfan Flufenamic acid++ Flunitrazepam Captopril Flurazepam Carbamazepine++ Fluroxene Carbromal++ Furosemide+ Carisoprodol++ Cefuroxime+ Glutethimide+ Cephalexin+ Glymidine Cephalosporins+ Gold sodium thiomalate Cephradine+ Gramicidin Chlorambucil+ Griseofulvin++ Chloramphenicol++ Guaifenesin Chlordiazepoxide++ Chlormezanone Halothane++ Chloroform Hydantoins++ Chlorpropamide++ Hydralazine Chlorzoxazone Hydrochlorothiazide+ Cimetidine Hydroxyzine Cinnarizine Clemastine Imipramine++ Clobazam+ Iproniazid Clomipramine Isoniazid+ Clonazepam+ Isopropyl antipyrine Clonidine Clorazepate Lidocaine Lofepramine Danazol Loprazolam Dapsone Diazepam+ Mefenamic acid+ Diclofenac Megestrol acetate Diethylpropion Mephenesin Dihydroergotamine mesylate++ Mepivacaine Diltiazem Meprobamate++ Dimenhydrinate++ Mercaptopurine Diphenhydramine Mercury compounds Dipyrone Mestranol Dixyrazine Methamphetamine Doxycycline Methotrexate Methoxyflurane Probenecid+ Methasuximide Progesterone++ Methyldopa++ Promethazine Methyprylon++ Propanidid+ Metodopramide+ Propofol Metronidazole Propoxyphene Metyrapone Pyrazinamide++ Miconazole Pyrrocaine Minoxidil Rifampin Nalidixic acid Nifedipine Scopolamine++ Nikethamide++ Secobarbital Nitrazepam Sodium oxybate Nitrofurantoin+ Sodium valproate+ Norethynodrel Spironolactone Nortriptyline Stanozolol Novobiocin Succinimides Sulfamethazine++ Oral contraceptives++ Sulfasalazine++ Orphenadrine++ Sulfinpyrazone Oxanamide Sulthiame Oxazepam+ Oxycodone Tamoxifen Oxymetazoline Terfenadine Oxyphenbutezone Tetracyclines+ Oxytetracycline Theophylline++ Thiopental++ Paramethadione Thioridazine Pargyline Tolazamide Pentazocine++ Tolbutamide Pentylenetetrazo++ Tranylcypromine Phenacetin Trazodone Phenelzine Trimethadione Phenobarbital++ Trimethoprim Phenoxybenzamine Trimipramine Phensuximide Verapamil Viloxazine Phenylbutezone+ Phenylhydrazine Phenytoin++ Piroxicam Pivampicillin++ Prazepam Prenylamine Prilocaine+ Primidone++