Safe Drugs for Patients with Acute Intermittent Porphyria, Variegate
Porphyria, Hereditary Coproporphyria, or ALA Dehydratase Deficiency
(Plumboporphyria)
from Scientific American Medicine, 12/96.
*Has produced conflicting results (occasionally positive but mainly
negative) in experiments on porphyrinogenicity. None of the safe drugs
listed has been associated with human porphyric attacks.
+Has produced conflicting results (some positive, some negative) in
experiments on porphyrinogenicity.
++Has been associated with acute attacks of porphyria.

Safe Drugs-------------------------------------------------------------

Acetaminophen                         Deferoxamine
Acetazolamide                         Demerol
Acetylcholine                         Dexamethasone
Acetylsalicylic acid                  Dextromoramide*
Acyclovir                             Diacetylmorphine
Adenosine monophosphate               Diazoxide
Adrenaline                            Dicyclomine
Adrenocorticotropic hormone           Diflunisal
(ACTH)                                Digoxin
Albuterol                             Dihydrocodeine
Alclofenac                            Dimercaprol
Allopurinol                           Dimethicone
Amiloride                             Diphenoxylate
Aminocaproic acid                     Disopyramide*
Amoxicillin                           Domperidone
Amphotericin B                        Doxepin
Ampicillin                            Doxorubicin
Ascorbic acid                         Droperidol
Aspirin                               
Atenolol                              Edetate calcium disodium
Atropine                              Ethacrynic acid
Azathioprine                          Ethambutol
                                      Ethinyl estradiol*
Beclomethasone dipropionate           Ethoheptazine citrate
Biguanides                            Fenbufen
Bromazopam*                           Fenoprofen
Bromides                              Fentanyl
Bumetanide                            Flucytosine*
Bupivacaine                           Flurbiprofen
Buprenorphine                         Folic acid
Buserelin                             Follicle-stimulating hormone
Butacaine sulfate                     (FSH)
                                      
Canthexanthin                         Gabapentin
Carbimazole                           Gentamicin
Beta carotene                         Glipizide
Chloral hydrate                       Glucagon
Chlormethiazole*                      Guanethidine
Chloroquine*                          
Chlorothiazide*                       Haloperidol
Chlorpheniramine                      Heme arginate
Chlorpromazine                        Heparin
Cimetidine                            Hexamine
Cisplatin                             Hydrocortisone
Clofibrate                            
Clomiphene citrate                    Indomethacin
Cloxacillin                           Insulin
Cocaine*                              Iron
Codeine phosphate                     
Colchicine                            Ketamine
Corticosteroids*                      Ketoprofen
Coumarins                             Ketotifen*
Cyclizine                             Labetalol
Cyclopropane                          
Cyproterone acetate*                  Licorice
                                      Lithium salts
Danthron                              Loperamide*
Lorazepam*                            Propofol
Luteinizing hormone releasing         Propranolol
hormone (LHRH)                        Propylthiouracil
                                      Proxymetacaine*
Magnesium sulfate                     Pseudoephedrine
Mebendazole                           Pyridoxine Pyrimethamine*
Mecamylamine                          
Meclizine                             Quinine
Melphalan*                            
Meperidine                            Ranitidine*
Mequitazine                           Reserpine
Metformin                             Resorcinol
Methadone                             Salbutamol
Methotrimeprazine*                    Senna
Methylphenidate                       Sodium bromide
Methyluracil                          Sodium fusidate
Metipranolol                          Streptomycin
Metoprolol                            Sulfadoxine
Mianserin                             Sulindac
Midazolam*                            Suxamethonium
Minaxolone                            Talampicillin
Morphine                              Temazepam
                                      Tetracaine
Nadolol                               Thiouracil
Naftidrofuryl oxalate                 Thyroxine
Naproxen                              Tiaprofenic acid
Natamycin                             Timolol maleate
Nefopam                               Alpha-Tocopherol acetate
Neostigmine                           Tolazoline
Nitroglycerin                         Tranexamic acid
Nitrous oxide                         Triamterene
                                      Triazolam
Oxybuprocaine                         Trichlormethiazide*
Oxyphenbutazone*                      Trifluoperazine
Oxytocin                              Trimethoprim-sulfamethoxazole*
                                      Tripelennamine
Pancuronium bromide*                  Tubocurarine
Paracetamol                           
Paraldehyde                           Vincristine
Penicillamine                         
Penicillin                            Warfarin
Pentolinium tartrate                  
Phenformin                            Zinc preparations (topical)
Phenoperidine
Phentolamine mesylate
Pipotiazine palmitate
Pirbuterol
Pirenzepine
Prazosin*
Prednisolone*
Primaquine
Probucol
Procaine
Prochlorperazine
Proguanine
Promazine
Propantheline bromide