Empyema ======= þ Empyema Etiology - can be caused by just about anything infectious including fungi - in 1930s-40s, was mostly pneumococcus and strep - in 1950s-60s, more Staph and gram negative rods - now known to be lots of aneaerobes in the empyemas as well [Chen KY, Hsueh PR, Liaw YS, et al: A 10-year experience with with bacteriology of acute thoracic empyema: emphasis on Klebsiella pneumoniae in patients with diabetes mellitus. Chest 117:1685, 2000.]