Erythema Multiforme and Stevens-Johnson Syndrome
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þ Lesions
 - Target lesions
 - Lesions on mucosa = SJS
 - Usually palms, soles, the dorsum of the hands, and the extensor
   surfaces

þ Etiology
 - main causes are viral infections, medications, malignancy; but no etiology
   found in about half of cases.
 - Drugs:
  + antibiotics: sulfa, PCN, cephalosporins
  + anticonvulsants: phenytoin and its relatives, carbamazepine, barbiturates
  + diuretics: Lasix, HCTZ
  + antiarrhythmics: procan, quinidine
  + allopurinol (high fatality rate); NSAIDs; phenothiazines

þ Natural History
 - 3-15% mortality for SJS

þ Treatment
 - IV gamma globulin reported to be extremely effective in quite a few case
   reports, no controlled studies.

Vs. TEN:  
< 10% is SJS, >30% is TEN, in between is overlap

Roof of TEN blister can be sent for frozen section, if complete 
slough, is TEN.