3. Treatment: i. pH < 7.6, asymptomatic (chloride-responsive assumed) a. volume depleted: give IV-NS and K+ (base amount of K+ on urine Cl-); see below. b. edematous but intravascularly depleted (CHF, nephrosis, cirrhosis): give albumin to  intravascular volume if appropriate, replete K+ agressively, and consider Diamox (see below) c. volume expanded (rare): give KCl po or IV ii. pH > 7.6, symptomatic (chloride-responsive assumed) a. monitored bed b. NH4Cl or HCl IV 1. 20-40 mEq/hr of 0.1 N or 0.15 N HCl through central line (NH4Cl can be given PO, but must be avoided in cirrhosis or renal failure because of NH3 buildup) 2. 100 mEq H+ should  HCO3- by 7 mEq/L 3. follow Q1H pH, pCO2, HCO3- 4. stop when pH < 7.6 and asymptomatic c. Acetazolamide (Diamox) 1. watch for  K+; must supplement with massive amounts KCl 2. 250 mg IV Q8H 3. stop when pH < 7.6 and pt. asymptomatic iii. non-chloride-responsive: urinary Cl- > 20 mEq/l means not chloride-responsive (rare), so problem is probably primary hyperaldo, or severe lack of K+ leading to HCO3- loss; give plenty of K+,. and give large doses of Aldactone (spironolactone) to block aldo receptors.