Intra-Articular Anaesthesia ==========================+ - giving intra-articular (IA) morphine in a dose of about 1 mg will give significant pain relief, and is blocked by IA naloxone, suggesting that there are indeed local opioid receptors. [Stein, C et al. Analgesic effect of intraarticular morphine after arthroscopic knee surgery. N Engl J Med 1991;325:1123.]